The Bulldogs winger celebrated the momentous occasion with a gritty 24-20 win over his former team, the Roosters, to momentarily send the blue and whites into the competition's top four.
Few players have garnered as much respect as Perrett over the years, so it came as no surprise to see '#Perrett250' trending on Twitter in Australia during the game.
Perrett ran through a guard of honour from his Canterbury teammates with his children, before the Roosters followed suit with a touching tribute after the full-time siren.
Having debuted back in 2004 against the Knights, Perrett said he never thought he'd one day call himself a '250-game player'.
Over the years he has developed into one of the most consistent wingers in the NRL; capable of finishing tries, safe under the high ball and always willing to make the hard yards coming out of trouble.